Pre-Operative MRI in HER-2 Receptor Positive and Her-2 Receptor Negative Breast Cancer: A Comparison
نویسندگان
چکیده
Objectives: MRI is the most sensitive modality for local staging of breast cancer. Herceptin receptor over-expression seen in 15% - 30% tumours, and associated with increased aggression, poorer prognosis, higher grade at diagnosis lymphatic dissemination. This study aimed evaluating role positive vs negative tumours. Methods: 193 pre-operative MRIs were performed 2021 162 Her-2 37 Recall rates further biopsies (ipsilateral/contralateral) assessed both groups, largest size was compared to pathological invasive cancer DCIS. Results: 36.4% tumours recalled; ipsilateral malignancy identified 13.6%. Contralateral 1.2%. 29.7% 16.2%. No contralateral The OR having foci on 0.83 (CI 0.3, 2.2). Pathological concordance 70.3% negative, 48.6% Discordance groups due overestimation (70.8% discordance; 89.4% discordance). Conclusions: Pre-operative did not detect significant additional Significant groups; frequent cause discordance groups. Advances Knowledge: compares features It demonstrates that there no multifocality or multicentricity but over-estimates 51% cancers.
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ژورنال
عنوان ژورنال: Advances in breast cancer research
سال: 2023
ISSN: ['2168-1589', '2168-1597']
DOI: https://doi.org/10.4236/abcr.2023.122005